A Proposed Method to Minimize Male Gamete Contribution to Aneuploidy in the Embryo Cohort
- Fecha: ESHRE Junio, 2018
- Revista: ESHRE 2018
- Autores: Alexis Melnick, Alessandra Parrella, Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo.
Summary: Microfluidic selection yields spermatozoa with the highest progressive motility and genomic integrity, enabling the generation of chromosomally normal embryos despite a history of recurrent, total aneuploid conceptuses.
What is known already: The presence of a male factor can negatively impact embryo cleavage and chromosomal status. In addition, dysfunction of the male genital tract increases sperm chromatin fragmentation that, particularly in cases of double strand breaks, can lead to aneuploidy of the male gamete. Thus, in couples with a relatively young female partner, the recurrent appearance of aneuploid embryos may reflect the contribution of the male gamete.
Limitations, reasons for caution: This is a pilot study on a small number of subjects. However, this microfluidic method is capable of selecting spermatozoa with better morphology, higher chromatin integrity, and presumably lower sperm aneuploidy, which may likely yield euploid embryos in couples with subtle male factor infertility.